About: Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis

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About: Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. (en)
Title	Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis (en)
skos:prefLabel	Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis (en)
skos:notation	RIV/00216224:14110/14:00075188!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Daněk, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	10752
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00075188
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mucoadhesive buccal films; Solvent casting method; Method of impregnation; Carmellose; Non-woven textile; Backing layer; In vitro testing; In vivo evaluation; Multivariate data analysis; Residence time (en)
http://linked.open.../riv/klicoveSlovo	Multivariate data analysis Backing layer Carmellose In vitro testing In vivo evaluation Method of impregnation Mucoadhesive buccal films Non-woven textile Residence time Solvent casting method
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CE1DF4ED38E5]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmaceutics and Biopharmaceutics
http://linked.open...in/vavai/riv/obor	FF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	86
http://linked.open...iv/tvurceVysledku	Doležel, Petr Gajdziok, Jan Landová, Hana Vetchý, David Daněk, Zdeněk Štembírek, Jan
http://linked.open...ain/vavai/riv/wos	000336111900020
issn	0939-6411
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ejpb.2013.12.002
http://localhost/t...ganizacniJednotka	14110

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