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  • Mantle cell lymphoma (MCL) is considered, with some exceptions, to be one of the most aggressive lymphomas, with relatively short median survival [1]. Th e biological hallmark of MCL is t(11;14)(q13;q32) resulting in cyclin D1 overexpression, which is not usually expressed in normal B cells [2]. Although the initial oncogenic translocation is acquired at the pre-B stage during the V(D)J recombination in the bone marrow [3], MCL is composed of mature B cells that grow in the mantle zone of lymphatic follicles and express the corresponding phenotype. To date, the oncogenic steps from the early event to the development of MCL have not been well documented. Rare cases of donor-derived malignancies can provide better insights into the biology and growth of different tumors under real conditions.
  • Mantle cell lymphoma (MCL) is considered, with some exceptions, to be one of the most aggressive lymphomas, with relatively short median survival [1]. Th e biological hallmark of MCL is t(11;14)(q13;q32) resulting in cyclin D1 overexpression, which is not usually expressed in normal B cells [2]. Although the initial oncogenic translocation is acquired at the pre-B stage during the V(D)J recombination in the bone marrow [3], MCL is composed of mature B cells that grow in the mantle zone of lymphatic follicles and express the corresponding phenotype. To date, the oncogenic steps from the early event to the development of MCL have not been well documented. Rare cases of donor-derived malignancies can provide better insights into the biology and growth of different tumors under real conditions. (en)
Title
  • Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma
  • Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma (en)
skos:prefLabel
  • Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma
  • Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma (en)
skos:notation
  • RIV/00216224:14110/14:00074943!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
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  • 51069
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  • RIV/00216224:14110/14:00074943
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • BONE-MARROW-TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; CLONAL IMMUNOGLOBULIN; RELAPSE; GENE (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [8A86F9F45A7C]
http://linked.open...i/riv/nazevZdroje
  • LEUKEMIA & LYMPHOMA
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http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Horký, Ondřej
  • Krejčí, Marta
  • Mayer, Jiří
  • Moulis, Mojmír
  • Pospíšilová, Šárka
  • Janíková, Andrea
  • Šálek, David
  • Tichý, Boris
  • Šupíková, Jana
  • Hanke, Ivo
  • Baumeisterova, A.
  • Mareckova, Andrea
http://linked.open...ain/vavai/riv/wos
  • 000340224100041
issn
  • 1042-8194
number of pages
http://bibframe.org/vocab/doi
  • 10.3109/10428194.2013.858150
http://localhost/t...ganizacniJednotka
  • 14110
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