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Description
  • Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy.
  • Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy. (en)
Title
  • Antitumour activities of sanguinarine and related alkaloids
  • Antitumour activities of sanguinarine and related alkaloids (en)
skos:prefLabel
  • Antitumour activities of sanguinarine and related alkaloids
  • Antitumour activities of sanguinarine and related alkaloids (en)
skos:notation
  • RIV/00216224:14110/14:00074837!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 3492
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00074837
http://linked.open...riv/jazykVysledku
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  • Apoptosis; Anti-proliferative activity; Benzophenanthridine alkaloids; cancer; sanguinarine (en)
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  • NL - Nizozemsko
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  • [ED35B443B90E]
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  • Phytochemistry reviews
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  • 13
http://linked.open...iv/tvurceVysledku
  • Slaninová, Iva
  • Táborská, Eva
  • Kantorová, Jana
  • Pěnčíková, Kristýna
  • Slanina, Jiří
http://linked.open...ain/vavai/riv/wos
  • 000331818000004
issn
  • 1568-7767
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s11101-013-9290-8
http://localhost/t...ganizacniJednotka
  • 14110
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