About: Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality

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About: Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: We hypothesized that genetic variability in genes encoding enzymes metabolizing glycolytic intermediates produced in excess under hyperglycemic conditions [i.e., transketolase ( TKT ), transaldolase, TKT-like protein 1, fructosamine 3-kinase ( FN3K ), glyoxalase 1 and glucose-6-phosphate dehydrogenase] could influence progression of diabetic nephropathy (DN) and diabetesrelated morbidity and mortality. Methods: A total of 19 single nucleotide polymorphisms (SNPs) in six candidate genes were studied in 314 type 2 diabetic subjects with variable stage of kidney disease (normo- and microalbuminuria, proteinuria, end-stage renal disease). SNP selection criteria were based on known functional effect and gene coverage. SNPs were detected using polymerase chain reaction based methods. Subjects were followed up for median of 38 months. Time-to-event analysis considered three end-points: 1) DN progression by at least one stage; 2) major cardiovascular event; and 3) all-cause mortality. Background: We hypothesized that genetic variability in genes encoding enzymes metabolizing glycolytic intermediates produced in excess under hyperglycemic conditions [i.e., transketolase ( TKT ), transaldolase, TKT-like protein 1, fructosamine 3-kinase ( FN3K ), glyoxalase 1 and glucose-6-phosphate dehydrogenase] could influence progression of diabetic nephropathy (DN) and diabetesrelated morbidity and mortality. Methods: A total of 19 single nucleotide polymorphisms (SNPs) in six candidate genes were studied in 314 type 2 diabetic subjects with variable stage of kidney disease (normo- and microalbuminuria, proteinuria, end-stage renal disease). SNP selection criteria were based on known functional effect and gene coverage. SNPs were detected using polymerase chain reaction based methods. Subjects were followed up for median of 38 months. Time-to-event analysis considered three end-points: 1) DN progression by at least one stage; 2) major cardiovascular event; and 3) all-cause mortality. (en)
Title	Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality (en)
skos:prefLabel	Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality (en)
skos:notation	RIV/00216224:14110/14:00074668!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT13198)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pácal, Lukáš Kuricová, Katarína Bartáková, Vendula Dvořáková, Veronika Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	18108
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00074668
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	advanced glycation end-products; diabetic nephropathy; fructosamine 3-kinase; glyoxalase; pentose phosphate pathway; transketolase (en)
http://linked.open.../riv/klicoveSlovo	fructosamine 3-kinase glyoxalase transketolase diabetic nephropathy pentose phosphate pathway advanced glycation end-products
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[0018BFF3D496]
http://linked.open...i/riv/nazevZdroje	Clinical Chemistry and Laboratory Medicine
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Pentose phosphate pathway as a potentially new therapeutic target in prevention of diabetic complications
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Olšovský, Jindřich Řehořová, Jitka Kaňková, Kateřina Pácal, Lukáš Tanhäuserová, Veronika Svojanovský, Jan Bělobrádková, Jana Kuricová, Katarína Bartáková, Vendula
http://linked.open...ain/vavai/riv/wos	000328687600011
issn	1434-6621
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1515/cclm-2012-0833
http://localhost/t...ganizacniJednotka	14110

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