About: Statins in oncological research: From experimental studies to clinical practice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many epidemiological and preclinical studies pointed to anti-tumor properties of statins, including anti-proliferative activities, apoptosis, decreased angiogenesis and metastasis. These processes play an important role in carcinogenesis and, therefore, the role of statins in cancer disease is being seriously discussed among oncologists. Anti-neoplastic properties of statins combined with an acceptable toxicity profile in the majority of individuals support their further development as anti-tumor drugs.The mechanism of action, current preclinical studies and clinical efficacy of statins are reviewed in this paper. Moreover, promising results have been reported regarding the statins' efficacy in some cancer types, especially in esophageal and colorectal cancers, and hepatocellular carcinoma. Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are commonly used drugs in the treatment of dyslipidemias, primarily raised cholesterol. Recently, many epidemiological and preclinical studies pointed to anti-tumor properties of statins, including anti-proliferative activities, apoptosis, decreased angiogenesis and metastasis. These processes play an important role in carcinogenesis and, therefore, the role of statins in cancer disease is being seriously discussed among oncologists. Anti-neoplastic properties of statins combined with an acceptable toxicity profile in the majority of individuals support their further development as anti-tumor drugs.The mechanism of action, current preclinical studies and clinical efficacy of statins are reviewed in this paper. Moreover, promising results have been reported regarding the statins' efficacy in some cancer types, especially in esophageal and colorectal cancers, and hepatocellular carcinoma. (en)
Title	Statins in oncological research: From experimental studies to clinical practice Statins in oncological research: From experimental studies to clinical practice (en)
skos:prefLabel	Statins in oncological research: From experimental studies to clinical practice Statins in oncological research: From experimental studies to clinical practice (en)
skos:notation	RIV/00216224:14110/14:00074348!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7AMB13FR011), P(ED1.100/02/0123), P(GA13-19910S), P(GBP302/12/G157)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jelínková, Šárka Rotrekl, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	47310
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00074348
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Anti-tumor properties; Cancer risk reduction; Cancer therapy; Carcinogenesis; Chemoprevention; Statins (en)
http://linked.open.../riv/klicoveSlovo	Cancer therapy Carcinogenesis Anti-tumor properties Cancer risk reduction Statins Chemoprevention
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EB9A70198592]
http://linked.open...i/riv/nazevZdroje	Critical Reviews in Oncology/Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Reprogramming of DMD-patient cells into cardiomyocytes - insights into molecular pathology of dilated cardiomyopathy Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC) Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Kružliak, Peter Rotrekl, Vladimír Kubatka, Peter Mladosievicova, Beata Jelínková, Šárka
http://linked.open...ain/vavai/riv/wos	000347130000012
issn	1040-8428
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.critrevonc.2014.08.002
http://localhost/t...ganizacniJednotka	14110

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