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rdf:type
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Description
| - The transverse (t-) tubular system serves to bring electrical signals deep inside the muscle cells to control mechanical responses. Our preliminary mathematical model of human ventricular cardiomyocyte incorporating t-tubular system [1] was improved by introducing description of latest experimental data related to morphology of human t-tubules and to specific properties of ionic currents. To describe the ion diffusion within t-tubular lumen, we partitioned the t-tubule compartment into nine concentric cylindrical segments. Using the model, we studied the effect of activity-induced concentration changes in the t-tubules on Ca2+ entry into the cell and the intracellular Ca2+ transients controlling the strength of cellular contraction. The values of some crucial parameters, unknown in human cardiomyocytes to date, were regarded as independent variables.
- The transverse (t-) tubular system serves to bring electrical signals deep inside the muscle cells to control mechanical responses. Our preliminary mathematical model of human ventricular cardiomyocyte incorporating t-tubular system [1] was improved by introducing description of latest experimental data related to morphology of human t-tubules and to specific properties of ionic currents. To describe the ion diffusion within t-tubular lumen, we partitioned the t-tubule compartment into nine concentric cylindrical segments. Using the model, we studied the effect of activity-induced concentration changes in the t-tubules on Ca2+ entry into the cell and the intracellular Ca2+ transients controlling the strength of cellular contraction. The values of some crucial parameters, unknown in human cardiomyocytes to date, were regarded as independent variables. (en)
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Title
| - EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE
- EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE (en)
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skos:prefLabel
| - EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE
- EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE (en)
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skos:notation
| - RIV/00216224:14110/13:00076830!RIV15-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/13:00076830
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - human heart; cardiac cell; t-tubule; quantitative modeling (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pásek, Michal
- Šimurda, Jiří
- Christé, Georges
- Hrabcová, Dana
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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