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  • Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancer patients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledge and optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens.
  • Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancer patients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledge and optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens. (en)
Title
  • Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
  • Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art (en)
skos:prefLabel
  • Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
  • Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art (en)
skos:notation
  • RIV/00216224:14110/13:00071767!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(EE2.3.20.0012), P(LM2011017)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 110855
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00071767
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • dendritic cells; therapeutic cancer vaccines; maturation cocktails; polarizing signal; homing signal (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [6C619630609E]
http://linked.open...i/riv/nazevZdroje
  • CRITICAL REVIEWS IN IMMUNOLOGY
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 33
http://linked.open...iv/tvurceVysledku
  • Michálek, Jaroslav
  • Strioga, Marius
  • Schijns, Virgil
  • Dobrovolskiene, Neringa T.
  • Felzmann, Thomas
  • Matúšková, Miroslava
  • Ostapenko, Valerijus
  • Powell, Daniel J. Jr.
http://linked.open...ain/vavai/riv/wos
  • 000326204600002
issn
  • 1040-8401
number of pages
http://bibframe.org/vocab/doi
  • 10.1615/CritRevImmunol.2013008033
http://localhost/t...ganizacniJednotka
  • 14110
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