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  • Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief.
  • Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. (en)
Title
  • microRNAs in nociceptive circuits as predictors of future clinical applications
  • microRNAs in nociceptive circuits as predictors of future clinical applications (en)
skos:prefLabel
  • microRNAs in nociceptive circuits as predictors of future clinical applications
  • microRNAs in nociceptive circuits as predictors of future clinical applications (en)
skos:notation
  • RIV/00216224:14110/13:00071637!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • R
http://linked.open...iv/cisloPeriodika
  • art. 33
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 88204
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00071637
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Antagomir; Biomarker; Chronic pain; miRNA expression patterns; miRNA polymorphisms; miRNA-based analgesic; miRNA-based diagnostics; Polymorphism (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [E8BD438E21BB]
http://linked.open...i/riv/nazevZdroje
  • Frontiers in Molecular Neuroscience
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Bednařík, Josef
  • Birklein, Frank
  • Favereaux, Alexandre
  • Greenberg, David
  • Heppenstall, Paul
  • Hüttenhofer, Alexander
  • Kress, Michaela
  • Kronenberg, Florian
  • Kuner, Rohini
  • Landry, Marc
  • Malcangio, Marzia
  • Mouritzen, Peter
  • Rittner, Heike
  • Sommer, Claudia
  • Soreq, Hermona
  • Trajanoski, Zlatko
  • Üçeyler, Nurcan
issn
  • 1662-5099
number of pages
http://bibframe.org/vocab/doi
  • 10.3389/fnmol.2013.00033
http://localhost/t...ganizacniJednotka
  • 14110
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