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Description
| - Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief.
- Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. (en)
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Title
| - microRNAs in nociceptive circuits as predictors of future clinical applications
- microRNAs in nociceptive circuits as predictors of future clinical applications (en)
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skos:prefLabel
| - microRNAs in nociceptive circuits as predictors of future clinical applications
- microRNAs in nociceptive circuits as predictors of future clinical applications (en)
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skos:notation
| - RIV/00216224:14110/13:00071637!RIV14-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/13:00071637
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Antagomir; Biomarker; Chronic pain; miRNA expression patterns; miRNA polymorphisms; miRNA-based analgesic; miRNA-based diagnostics; Polymorphism (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Frontiers in Molecular Neuroscience
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bednařík, Josef
- Birklein, Frank
- Favereaux, Alexandre
- Greenberg, David
- Heppenstall, Paul
- Hüttenhofer, Alexander
- Kress, Michaela
- Kronenberg, Florian
- Kuner, Rohini
- Landry, Marc
- Malcangio, Marzia
- Mouritzen, Peter
- Rittner, Heike
- Sommer, Claudia
- Soreq, Hermona
- Trajanoski, Zlatko
- Üçeyler, Nurcan
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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