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  • The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed.
  • The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed. (en)
Title
  • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
  • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer (en)
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  • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
  • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer (en)
skos:notation
  • RIV/00216224:14110/13:00069863!RIV14-MSM-14110___
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  • 76270
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  • RIV/00216224:14110/13:00069863
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  • colorectal cancer; histopathology; gene expression; molecular heterogeneity (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9A07D2BD1FFC]
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  • JOURNAL OF PATHOLOGY
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  • 231
http://linked.open...iv/tvurceVysledku
  • Budinská, Eva
  • Delorenzi, Mauro
  • Popovici, Vlad
  • Tejpar, Sabine
  • Bosman, Fred
  • Di Narzo, Antonio Fabio
  • Giovanni, D Ario
  • Hodgson, John Graeme
  • Lapique, Nicolas
  • Roth, Arnaud
  • Sikora, Katarzyna Otylia
  • Weinrich, Scott
  • Yan, Pu
http://linked.open...ain/vavai/riv/wos
  • 000322761500008
issn
  • 0022-3417
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/path.4212
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  • 14110
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