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  • A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium.
  • A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. (en)
Title
  • Vitamin D and cardiovascular diseases
  • Vitamin D and cardiovascular diseases (en)
skos:prefLabel
  • Vitamin D and cardiovascular diseases
  • Vitamin D and cardiovascular diseases (en)
skos:notation
  • RIV/00216224:14110/13:00069848!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • 114231
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  • RIV/00216224:14110/13:00069848
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  • vitamin D; vitamin D receptor; hypertension; ischemic heart disease; cardiac failure (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • FR - Francouzská republika
http://linked.open...ontrolniKodProRIV
  • [C1449597111A]
http://linked.open...i/riv/nazevZdroje
  • Journal of Aging Research & Clinical Practice
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  • 2
http://linked.open...iv/tvurceVysledku
  • Meluzínová, Hana
  • Weber, Pavel
  • Matějovská Kubešová, Hana
  • Polcarová, Vlasta
  • Bielaková, Katarína
  • Fernandová, Emmanuela
  • Matejovsky, J.
issn
  • 2258-8094
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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