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  • It has long been shown that therapeutic ultrasound has the potential to affect cells surfaces and membranes. In this study, the effects of ultrasound in near field mode, the anti-cancer drug carboplatin and their combined application was studied on human carcinoma cells A2780. Four modes of treatment were used: exposure to ultrasonic field, application of carboplatin, exposure to ultrasound followed by carboplatin and carboplatin treatment followed by exposure to near field ultrasound. The value of viability was measured by standard MTT test. The value of ultrasound intensity was set 1 Wcm-2 and 1 MHz frequency was used. The real value of acoustic pressure during in vitro experiments was assessed by hydrophone. The results showed that a combined effect of ultrasound and carboplatin influenced the viability of human carcinoma cells A2780 more than the application of ultrasound or carboplatin alone.
  • It has long been shown that therapeutic ultrasound has the potential to affect cells surfaces and membranes. In this study, the effects of ultrasound in near field mode, the anti-cancer drug carboplatin and their combined application was studied on human carcinoma cells A2780. Four modes of treatment were used: exposure to ultrasonic field, application of carboplatin, exposure to ultrasound followed by carboplatin and carboplatin treatment followed by exposure to near field ultrasound. The value of viability was measured by standard MTT test. The value of ultrasound intensity was set 1 Wcm-2 and 1 MHz frequency was used. The real value of acoustic pressure during in vitro experiments was assessed by hydrophone. The results showed that a combined effect of ultrasound and carboplatin influenced the viability of human carcinoma cells A2780 more than the application of ultrasound or carboplatin alone. (en)
Title
  • Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells
  • Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells (en)
skos:prefLabel
  • Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells
  • Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells (en)
skos:notation
  • RIV/00216224:14110/13:00069140!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 71635
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00069140
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • carboplatin; ultrasoun; viability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [F263DC1B7532]
http://linked.open...i/riv/nazevZdroje
  • Indian Journal of Biochemistry & Biophysics
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Bernard, Vladan
  • Mornstein, Vojtěch
  • Bourek, Aleš
http://linked.open...ain/vavai/riv/wos
  • 000325058800006
issn
  • 0301-1208
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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