About: Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology     Goto   Sponge   NotDistinct   Permalink

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  • With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
  • With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers. (en)
Title
  • Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
  • Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology (en)
skos:prefLabel
  • Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
  • Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology (en)
skos:notation
  • RIV/00216224:14110/13:00069034!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika
  • 42
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 103353
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00069034
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [378FBF08596E]
http://linked.open...i/riv/nazevZdroje
  • Journal of Hematology & Oncology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Demlová, Regina
  • Pilátová, Kateřina
  • Greplová, Kristína
  • Zdražilová Dubská, Lenka
  • Klement, Giannoula Lakka
  • Bencsiková, Beatrix
http://linked.open...ain/vavai/riv/wos
  • 000321009900001
issn
  • 1756-8722
number of pages
http://bibframe.org/vocab/doi
  • 10.1186/1756-8722-6-42
http://localhost/t...ganizacniJednotka
  • 14110
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