About: Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart     Goto   Sponge   NotDistinct   Permalink

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  • Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, guinea pig and rabbit isolated hearts were perfused according to Langendorff under strictly identical conditions. The heart rate and arrhythmia were monitored during ischemia and reperfusion periods at defined time intervals; the production of hydroxyl radical was determined by HPLC as 2.5-dihydroxybenzoic acid (2.5-DHBA) formed by salicylic acid hydroxylation. Relationship between arrhythmias and production of 2.5-DHBA was studied. The inter-species differences were observed in timing of arrhythmias onset and their severity, and in the production of 2.5-DHBA in both ischemia and reperfusion.
  • Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, guinea pig and rabbit isolated hearts were perfused according to Langendorff under strictly identical conditions. The heart rate and arrhythmia were monitored during ischemia and reperfusion periods at defined time intervals; the production of hydroxyl radical was determined by HPLC as 2.5-dihydroxybenzoic acid (2.5-DHBA) formed by salicylic acid hydroxylation. Relationship between arrhythmias and production of 2.5-DHBA was studied. The inter-species differences were observed in timing of arrhythmias onset and their severity, and in the production of 2.5-DHBA in both ischemia and reperfusion. (en)
Title
  • Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart
  • Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart (en)
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  • Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart
  • Hydroxyl radicals’ production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart (en)
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  • RIV/00216224:14110/13:00068604!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • S, Z(MSM0021622402)
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  • 2
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  • 78512
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  • RIV/00216224:14110/13:00068604
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  • Arrhythmia; Guinea pig; Hydroxyl radical; Rabbit; Rat (en)
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  • SK - Slovenská republika
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  • [ED7FA5B2E277]
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  • General Physiology and Biophysics
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  • 32
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  • Jarkovský, Jiří
  • Táborská, Eva
  • Nováková, Marie
  • Paulová, Hana
  • Stračina, Tibor
http://linked.open...ain/vavai/riv/wos
  • 000320092300008
http://linked.open...n/vavai/riv/zamer
issn
  • 0231-5882
number of pages
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  • 10.4149/gpb_2013016
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  • 14110
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