About: Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients

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About: Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections. Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections. (en)
Title	Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients (en)
skos:prefLabel	Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients (en)
skos:notation	RIV/00216224:14110/13:00068281!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7E08062)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Litzman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	94893
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00068281
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	autoimmune cytopenia; common variable immunodeficiency; splenectomy; splenomegaly (en)
http://linked.open.../riv/klicoveSlovo	autoimmune cytopenia common variable immunodeficiency splenomegaly splenectomy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E6044CBA2B75]
http://linked.open...i/riv/nazevZdroje	Clinical and Experimental Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	30 (xsd:int)
http://linked.open...vavai/riv/projekt	Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	172
http://linked.open...iv/tvurceVysledku	Chapel, H. Litzman, Jiří Warnatz, K. Kutukculer, N. Jones, A. Gaspar, H. B. Plebani, A. Grimbacher, B. Lougaris, V. Quinti, I. Alecsandru, D. Baumann, U. Carbone, J. Contreras, R. Ernst, D. Espanol, T. Fernandez-Cruz, E. Goldacker, S. Gonzalez-Granado, L. I. Hammarstrom, L. Huissoon, A. P. Ibrahim, M. A. A. Kiani-Alikhan, S. Lucas, M. Martini, H. McEwen, D. Schmidt, R. E. Vidaller, A. Winterhalter, C. Wong, G. K.
http://linked.open...ain/vavai/riv/wos	000316212200008
issn	0009-9104
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/cei.12039
http://localhost/t...ganizacniJednotka	14110

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