About: PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice     Goto   Sponge   NotDistinct   Permalink

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  • Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify cooperating pathways to leukemogenesis we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice, which harbor an endogenous murine leukemia virus that causes acute myeloid leukemia. Approximately half of leukemias that arose in this cross showed features of acute promyelocytic leukemia. We identified 22 proviral insertions sites in acute promyelocytic-like leukemias and focused our analysis on insertion at Sox4, a HMG box transcription factor. Using a transplant model, cooperation between PML-RARalpha and Sox4 was confirmed with increased penetrance and reduced latency of disease. Interestingly, karyotypic analysis revealed cytogenetic changes suggesting that the factors combined to initiate but not complete leukemic transformation.
  • Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify cooperating pathways to leukemogenesis we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice, which harbor an endogenous murine leukemia virus that causes acute myeloid leukemia. Approximately half of leukemias that arose in this cross showed features of acute promyelocytic leukemia. We identified 22 proviral insertions sites in acute promyelocytic-like leukemias and focused our analysis on insertion at Sox4, a HMG box transcription factor. Using a transplant model, cooperation between PML-RARalpha and Sox4 was confirmed with increased penetrance and reduced latency of disease. Interestingly, karyotypic analysis revealed cytogenetic changes suggesting that the factors combined to initiate but not complete leukemic transformation. (en)
Title
  • PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice
  • PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice (en)
skos:prefLabel
  • PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice
  • PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice (en)
skos:notation
  • RIV/00216224:14110/13:00067529!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
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  • 3
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  • 96525
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00067529
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  • Acute promyelocytic leukemia; PML-RAR alpha; SOX4; mice (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IT - Italská republika
http://linked.open...ontrolniKodProRIV
  • [423080616929]
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  • Haematologica-The Hematology Journal
http://linked.open...in/vavai/riv/obor
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http://linked.open...v/svazekPeriodika
  • 98
http://linked.open...iv/tvurceVysledku
  • Ševčíková, Sabina
  • Himmel, Karen L.
  • Jones, Letetia
  • Kogan, Scott C.
  • Largaespada, David A.
  • Le Beau, Michelle M.
  • Maunakea, Mei Lin
  • Omidvar, Nader
  • Tennant, Thelma R.
  • Yin, Bin
http://linked.open...ain/vavai/riv/wos
  • 000317530600019
issn
  • 0390-6078
number of pages
http://bibframe.org/vocab/doi
  • 10.3324/haematol.2011.057067
http://localhost/t...ganizacniJednotka
  • 14110
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