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  • Modern molecular and cytogenetic approaches have furthered progress in our understanding of MM biology and have led to the development of targeted therapy that has improved management of this incurable disease. Novel agents such as bortezomib, lenalidomide or thalidomide, have increased median survival rates and improved prospects for MM patients resistant to conventional therapy [1, 2]. Despite these therapeutic advances, MM remains a very difficult disease to treat still accompanied by the threat of repeated relapses with a fatal ending. These observations indicate that at least some of the MM cells are not targeted efficiently by current drug therapies. The existence of such persistent populations, called myeloma stem cells (MSC) or myeloma-initiating cells (MIC) has been suspected for more than two decades. However, the cells of origin remain elusive [3-9]. Timeline of growing knowledge about putative MSC is displayed in Figure 1.
  • Modern molecular and cytogenetic approaches have furthered progress in our understanding of MM biology and have led to the development of targeted therapy that has improved management of this incurable disease. Novel agents such as bortezomib, lenalidomide or thalidomide, have increased median survival rates and improved prospects for MM patients resistant to conventional therapy [1, 2]. Despite these therapeutic advances, MM remains a very difficult disease to treat still accompanied by the threat of repeated relapses with a fatal ending. These observations indicate that at least some of the MM cells are not targeted efficiently by current drug therapies. The existence of such persistent populations, called myeloma stem cells (MSC) or myeloma-initiating cells (MIC) has been suspected for more than two decades. However, the cells of origin remain elusive [3-9]. Timeline of growing knowledge about putative MSC is displayed in Figure 1. (en)
Title
  • Heterogeneity and Plasticity of Multiple Myeloma
  • Heterogeneity and Plasticity of Multiple Myeloma (en)
skos:prefLabel
  • Heterogeneity and Plasticity of Multiple Myeloma
  • Heterogeneity and Plasticity of Multiple Myeloma (en)
skos:notation
  • RIV/00216224:14110/13:00067049!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GAP304/10/1395), Z(MSM0021622434)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 77261
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/13:00067049
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Multiple Myeloma (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [ECA9F3A4583B]
http://linked.open...i/riv/mistoVydani
  • Rijeka
http://linked.open...vEdiceCisloSvazku
  • Neuveden
http://linked.open...i/riv/nazevZdroje
  • Multiple Myeloma - A Quick Reflection on the Fast Progress
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hájek, Roman
  • Ševčíková, Sabina
  • Šváchová, Hana
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • InTech
https://schema.org/isbn
  • 9789535110835
http://localhost/t...ganizacniJednotka
  • 14110
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