About: Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules. Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules. (en)
Title	Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture (en)
skos:prefLabel	Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture (en)
skos:notation	RIV/00216224:14110/13:00066243!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GAP301/10/1971), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hampl, Aleš Bárta, Tomáš Doležalová, Dáša Holubcová, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	64479
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00066243
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human embryonic stem cells; cell cycle; culture adaptation; long-term culture (en)
http://linked.open.../riv/klicoveSlovo	culture adaptation long-term culture cell cycle human embryonic stem cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C950A1F66411]
http://linked.open...i/riv/nazevZdroje	Experimental Biology and Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Expression, signaling and function of Death Receptors in human embryonic stem cells. St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	238
http://linked.open...iv/tvurceVysledku	Hampl, Aleš Bárta, Tomáš Doležalová, Dáša Holubcová, Zuzana
http://linked.open...ain/vavai/riv/wos	000318188900003
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1535-3702
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1535370213480711
http://localhost/t...ganizacniJednotka	14110

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