About: Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib

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About: Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prognostic impact of specific chromosomal aberrations in patients with relapsed multiple myeloma (MM) treated with the novel agents is briefly described. We analyzed the prognostic value of an extended panel of chromosomal aberrations [del(13)(q14), del(17)(p13), t(4;14)(p16;q32), gain(1)(q21), and hyperdiploidy] by using the technique of interphase fluorescence in situ hybridization in a cohort of 102 patients with relapsed MM treated with thalidomide- or bortezomib-based protocols. We conclude that bortezomib-based protocols are able to partially overcome the negative prognostic impact of the tested chromosomal abnormalities in patients with relapsed MM. Prognostic impact of specific chromosomal aberrations in patients with relapsed multiple myeloma (MM) treated with the novel agents is briefly described. We analyzed the prognostic value of an extended panel of chromosomal aberrations [del(13)(q14), del(17)(p13), t(4;14)(p16;q32), gain(1)(q21), and hyperdiploidy] by using the technique of interphase fluorescence in situ hybridization in a cohort of 102 patients with relapsed MM treated with thalidomide- or bortezomib-based protocols. We conclude that bortezomib-based protocols are able to partially overcome the negative prognostic impact of the tested chromosomal abnormalities in patients with relapsed MM. (en)
Title	Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib (en)
skos:prefLabel	Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib (en)
skos:notation	RIV/00216224:14110/13:00065580!RIV14-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7E12070), P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT12130), P(NT13190), P(NT13492)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Melicharová, Hana Beránková, Kristina Smetana, Jan Penka, Miroslav Almáši, Martina Ševčíková, Sabina Májková, Petra Kuglík, Petr Jarkovský, Jiří Hájek, Roman Němec, Pavel Mikulášová, Aneta Grešliková, Henrieta Zaoralová, Romana Kupská, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	76148
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065580
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; Thalidomide; Bortezomib; Chromosomal aberrations; FISH; Survival (en)
http://linked.open.../riv/klicoveSlovo	Survival Bortezomib Chromosomal aberrations FISH Multiple myeloma Thalidomide
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FA0BD89C7678]
http://linked.open...i/riv/nazevZdroje	Clinical lymphoma, myeloma & leukemia
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	15 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma Role of genetic abnormalities in development and progression of precancerosis monoclonal gammopathy of undetermined significance Complex analysis of importance and pathogenesis of extramedullary relapse in patients with multiple myeloma Optimizing targets and therapeutics in high risk and refractory multiple myeloma
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Adam, Zdeněk Hájek, Roman Jarkovský, Jiří Krejčí, Marta Kuglík, Petr Penka, Miroslav Smetana, Jan Ševčíková, Sabina Němec, Pavel Mikulášová, Aneta Sandecká, Viera Zahradová, Lenka Fröhlich, Jan Grešliková, Henrieta Zaoralová, Romana Kupská, Renata Almaši, Martina Beránková, Kristina Jurczyszyn, Arthur Kaisarová, Petra Melicharová, Hana
http://linked.open...ain/vavai/riv/wos	000319248400005
issn	2152-2650
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.clml.2012.11.012
http://localhost/t...ganizacniJednotka	14110

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