About: Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo

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About: Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of the colon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27) in comparison with biopsies from the adjacent normal tissue. Colon cancer biopsies were used to study the cell populations with an upregulated level of expression of API-5 more closely. Using a magnetic bead based selection for the epithelial cell marker EpCAM, we purified epithelial cells from the tumor and control tissues and analyzed these cells for API-5 expression by western immunoblotting. Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of the colon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27) in comparison with biopsies from the adjacent normal tissue. Colon cancer biopsies were used to study the cell populations with an upregulated level of expression of API-5 more closely. Using a magnetic bead based selection for the epithelial cell marker EpCAM, we purified epithelial cells from the tumor and control tissues and analyzed these cells for API-5 expression by western immunoblotting. (en)
Title	Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo (en)
skos:prefLabel	Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo (en)
skos:notation	RIV/00216224:14110/12:00065918!RIV14-MSM-14110___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(2B06060), P(GA301/09/0587), P(GA305/09/1526), P(GAP301/11/1730), P(GAP305/11/0752), P(GD303/09/H048), V, Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Jíra, Miroslav Kysela, Petr Kozubík, Alois Hofmanová, Jiřina Kala, Zdeněk Krejčí, Pavel Chlebová, Katarína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	123227
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00065918
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis inhibitor 5; anti-apoptosis clone 11; carcinoma; human; apoptosis; magnetic bead selection (en)
http://linked.open.../riv/klicoveSlovo	carcinoma human anti-apoptosis clone 11 apoptosis inhibitor 5 magnetic bead selection apoptosis
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[A6E4D23EAC6E]
http://linked.open...i/riv/nazevZdroje	Oncology Letters
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Increasing the efficacy of the diagnostics and treatment of gastro-esophageal reflux disease. The role of extracellular matrix-mediated cell adhesion in maintenance of colonic tissue homeostasis and in colon carcinogenesis Molecular mechanisms of selected pathological processes in the cell Changes of lipid metabolism and composition during colorectal carcinogenesis - the effects of butyrate and polyunsaturated fatty acids Novel pathways of FGFR3 signaling in achondroplasia Molecular basis of FGFR3 signal transduction in skeletal dysplasia
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Jíra, Miroslav Kala, Zdeněk Kozubík, Alois Krejčí, Pavel Hýžďalová, Martina Kočí, Lenka Kysela, Petr Chlebová, Katarína
http://linked.open...ain/vavai/riv/wos	000301307600033
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1792-1074
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.3892/ol.2012.593
http://localhost/t...ganizacniJednotka	14110

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