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  • Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based on these activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role.
  • Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based on these activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role. (en)
  • Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based on these activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role. (cs)
Title
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy? (en)
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy? (cs)
skos:prefLabel
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy? (en)
  • Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy? (cs)
skos:notation
  • RIV/00216224:14110/12:00062695!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 177610
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/12:00062695
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • vitamin D - vitamin D receptors - tumours - sun (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [50BA61F722E2]
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Matějovská Kubešová, Hana
  • Bielaková, Katarína
  • Finne Soveri, Harriet
  • Topinkova, Eva
http://localhost/t...ganizacniJednotka
  • 14110
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