About: Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dendritic cell (DC) immunotherapy is capable of generating tumour-specific immune responses. Different maturation strategies were previously tested to obtain DC capable of anti-cancer responses in vitro, usually with limited clinical benefit. Mutual comparison of currently used maturation strategies and subsequent complex evaluation of DC functions and their stimulatory capacity on T cells was performed in this study to optimize the DC vaccination strategy for further clinical application. DC were generated from monocytes using granulocyte–macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, pulsed with whole tumour cell lysate and then matured with one of five selected maturation strategies or cultured without additional maturation stimulus. DC were characterized with regard to their surface marker expression, cytokine profiles, migratory capacity, allogeneic and autologous T cell stimulatory capacity as well as their specific cytotoxicity against tumour antigens. Dendritic cell (DC) immunotherapy is capable of generating tumour-specific immune responses. Different maturation strategies were previously tested to obtain DC capable of anti-cancer responses in vitro, usually with limited clinical benefit. Mutual comparison of currently used maturation strategies and subsequent complex evaluation of DC functions and their stimulatory capacity on T cells was performed in this study to optimize the DC vaccination strategy for further clinical application. DC were generated from monocytes using granulocyte–macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, pulsed with whole tumour cell lysate and then matured with one of five selected maturation strategies or cultured without additional maturation stimulus. DC were characterized with regard to their surface marker expression, cytokine profiles, migratory capacity, allogeneic and autologous T cell stimulatory capacity as well as their specific cytotoxicity against tumour antigens. (en)
Title	Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy (en)
skos:prefLabel	Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy (en)
skos:notation	RIV/00216224:14110/12:00061849!RIV13-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B06058), P(NT11137)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Michálek, Jaroslav Burešová, Ivana Vopěnková, Kateřina Mollová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	128174
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00061849
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer immunotherapy; cytotoxicity; dendritic cell; interleukin-12; maturation; migration (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity migration dendritic cell interleukin-12 maturation cancer immunotherapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[15A211C952C0]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular and Molecular Medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Anti-tumour therapy - vaccination with dendritic cells in patients with metastatic renal cell carcinoma. Phase II clinical study. Safer biotechnology of the allogeneic hematopoietic stem cells in solid and hematological cancer as an adoptive immunotherapy
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Burešová, Ivana Mollová, Klára Vopěnková, Kateřina
http://linked.open...ain/vavai/riv/wos	000310555200026
issn	1582-1838
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1582-4934.2012.01614.x
http://localhost/t...ganizacniJednotka	14110

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