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  • The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insight into the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor.
  • The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insight into the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor. (en)
Title
  • TGF-beta - an excellent servant but a bad master
  • TGF-beta - an excellent servant but a bad master (en)
skos:prefLabel
  • TGF-beta - an excellent servant but a bad master
  • TGF-beta - an excellent servant but a bad master (en)
skos:notation
  • RIV/00216224:14110/12:00061365!RIV13-MZ0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NT11154), P(NT12130), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika
  • %22art. 183%22
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  • 174170
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/12:00061365
http://linked.open...riv/jazykVysledku
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  • TGF-beta; SMAD proteins; Oncogene; Suppressor; Solid tumors; Leukemia; Multiple myeloma (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [D70CD5892C59]
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  • Journal of Translational Medicine
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  • 10
http://linked.open...iv/tvurceVysledku
  • Hájek, Roman
  • Ševčíková, Sabina
  • Kubiczková, Lenka
  • Sedlaříková, Lenka
http://linked.open...ain/vavai/riv/wos
  • 000311108500001
http://linked.open...n/vavai/riv/zamer
issn
  • 1479-5876
number of pages
http://bibframe.org/vocab/doi
  • 10.1186/1479-5876-10-183
http://localhost/t...ganizacniJednotka
  • 14110
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