About: TGF-beta - an excellent servant but a bad master

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About: TGF-beta - an excellent servant but a bad master Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.translational-medicine.com/content/10/1/183
Description	The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insight into the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor. The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insight into the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor. (en)
Title	TGF-beta - an excellent servant but a bad master TGF-beta - an excellent servant but a bad master (en)
skos:prefLabel	TGF-beta - an excellent servant but a bad master TGF-beta - an excellent servant but a bad master (en)
skos:notation	RIV/00216224:14110/12:00061365!RIV13-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NT11154), P(NT12130), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	%22art. 183%22
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ševčíková, Sabina Hájek, Roman Kubiczková, Lenka Sedlaříková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	174170
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00061365
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TGF-beta; SMAD proteins; Oncogene; Suppressor; Solid tumors; Leukemia; Multiple myeloma (en)
http://linked.open.../riv/klicoveSlovo	Oncogene SMAD proteins Solid tumors Suppressor Multiple myeloma Leukemia TGF-beta
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D70CD5892C59]
http://linked.open...i/riv/nazevZdroje	Journal of Translational Medicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Complex analysis of importance and pathogenesis of extramedullary relapse in patients with multiple myeloma
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Hájek, Roman Ševčíková, Sabina Kubiczková, Lenka Sedlaříková, Lenka
http://linked.open...ain/vavai/riv/wos	000311108500001
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	1479-5876
number of pages	24 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1479-5876-10-183
http://localhost/t...ganizacniJednotka	14110

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