About: Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF     Goto   Sponge   NotDistinct   Permalink

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  • Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MMderived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.
  • Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MMderived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway. (en)
Title
  • Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF
  • Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF (en)
skos:prefLabel
  • Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF
  • Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF (en)
skos:notation
  • RIV/00216224:14110/12:00060588!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 125499
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/12:00060588
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • human; melanoma; potential biomarker; BCSC-1; tumor suppressor; MITF; proliferation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [69347D4FE895]
http://linked.open...i/riv/nazevZdroje
  • Pigment Cell & Melanoma Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 25
http://linked.open...iv/tvurceVysledku
  • Budinská, Eva
  • Delorenzi, Mauro
  • Abraham, Shahnaz
  • Anghel, Silvia I.
  • Boliganl, Kayluz F.
  • Colombetti, Sara
  • Correa-Rochal, Rafael
  • Fisher, David E.
  • Fontao, Lionel
  • Ghanem, Ghanem E.
  • Lévy, Frederic
  • Mariotti, Agnese
  • Piguet, Vincent
  • Rimoldi, Donata
http://linked.open...ain/vavai/riv/wos
  • 000305511200012
issn
  • 1755-1471
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/j.1755-148X.2012.01018.x
http://localhost/t...ganizacniJednotka
  • 14110
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