About: Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375—the Study of Sonodynamic Therapy     Goto   Sponge   NotDistinct   Permalink

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  • Sonodynamic therapy, an effect of low-power ultrasound field and the anticancer drug cisplatin was studied in vitro on human melanoma cells A375. The viability of cells has been studied by standard MTT test according to different modes of treatment: application of cisplatin alone, exposure of ultrasound field alone, exposure to ultrasound followed by cisplatin, and application of cisplatin followed by exposure to ultrasound. Ultrasound was used at a therapeutical intensity of 1 Wcm-2 for 10 min. Concentration of cisplatin in the cell suspension was always 2,3 mikroM. The results show that sonodynamic therapy is one of the possibilities how to intensify standard cytostatic therapy. This conclusion is supported by reducing the viability of studied cells, especially 72 hours after the treatment. The time sequence of application of ultrasonic field and cytostatics appears to be a significant factor affecting the changes in cell’s viability.
  • Sonodynamic therapy, an effect of low-power ultrasound field and the anticancer drug cisplatin was studied in vitro on human melanoma cells A375. The viability of cells has been studied by standard MTT test according to different modes of treatment: application of cisplatin alone, exposure of ultrasound field alone, exposure to ultrasound followed by cisplatin, and application of cisplatin followed by exposure to ultrasound. Ultrasound was used at a therapeutical intensity of 1 Wcm-2 for 10 min. Concentration of cisplatin in the cell suspension was always 2,3 mikroM. The results show that sonodynamic therapy is one of the possibilities how to intensify standard cytostatic therapy. This conclusion is supported by reducing the viability of studied cells, especially 72 hours after the treatment. The time sequence of application of ultrasonic field and cytostatics appears to be a significant factor affecting the changes in cell’s viability. (en)
Title
  • Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375—the Study of Sonodynamic Therapy
  • Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375—the Study of Sonodynamic Therapy (en)
skos:prefLabel
  • Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375—the Study of Sonodynamic Therapy
  • Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375—the Study of Sonodynamic Therapy (en)
skos:notation
  • RIV/00216224:14110/12:00060116!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 175828
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/12:00060116
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • A375; cisplatin; ultrasound; viability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [B148B98918F2]
http://linked.open...i/riv/nazevZdroje
  • Ultrasound in Medicine and Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 38
http://linked.open...iv/tvurceVysledku
  • Bernard, Vladan
  • Mornstein, Vojtěch
  • Škorpíková, Jiřina
  • Jaroš, Josef
http://linked.open...ain/vavai/riv/wos
  • 000304995600014
issn
  • 0301-5629
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.ultrasmedbio.2012.02.006
http://localhost/t...ganizacniJednotka
  • 14110
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