About: Estimation of rate constants of drug binding to open channels of cardiac transient outward current

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito, is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence, of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method. An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito, is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence, of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method. (en)
Title	Estimation of rate constants of drug binding to open channels of cardiac transient outward current Estimation of rate constants of drug binding to open channels of cardiac transient outward current (en)
skos:prefLabel	Estimation of rate constants of drug binding to open channels of cardiac transient outward current Estimation of rate constants of drug binding to open channels of cardiac transient outward current (en)
skos:notation	RIV/00216224:14110/12:00059510!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Šimurda, Jiří Šimurdová, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	134795
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00059510
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ito channel; Drug binding; Open state; Rate constants; Mathematical model (en)
http://linked.open.../riv/klicoveSlovo	Mathematical model Rate constants Drug binding Ito channel Open state
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C3CD16251F0B]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Šimurda, Jiří Šimurdová, Milena
http://linked.open...ain/vavai/riv/wos	000301816200013
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	0231-5882
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/gpb_2012_013
http://localhost/t...ganizacniJednotka	14110

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