About: Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.

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About: Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. Methods: We analyzed Treg cells in peripheral blood (n = 207) and bone marrow (n = 202) of pre-malignant and malignant MM patients using flow cytometry. Treg cells and their subsets from MM patients and healthy volunteers were functionally evaluated for their suppressive property. A cohort of 25 patients was analyzed for lymphocytes, CD4 T cells and Treg cells before and after treatment with cyclophosphamide, thalidomide plus dexamethasone (CTD). Results: We found elevated frequencies of Treg cells in newly diagnosed (P<0.01) and relapsed MM patients (P<0.0001) compared to healthy volunteers. Also, Treg subsets including naive (P = 0.015) and activated (P = 0.036) Treg cells were significantly increased in MM patients compared to healthy volunteers. Background: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. Methods: We analyzed Treg cells in peripheral blood (n = 207) and bone marrow (n = 202) of pre-malignant and malignant MM patients using flow cytometry. Treg cells and their subsets from MM patients and healthy volunteers were functionally evaluated for their suppressive property. A cohort of 25 patients was analyzed for lymphocytes, CD4 T cells and Treg cells before and after treatment with cyclophosphamide, thalidomide plus dexamethasone (CTD). Results: We found elevated frequencies of Treg cells in newly diagnosed (P<0.01) and relapsed MM patients (P<0.0001) compared to healthy volunteers. Also, Treg subsets including naive (P = 0.015) and activated (P = 0.036) Treg cells were significantly increased in MM patients compared to healthy volunteers. (en)
Title	Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. (en)
skos:prefLabel	Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. (en)
skos:notation	RIV/00216224:14110/12:00057825!RIV13-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NT12130), P(NT12425), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Říhová, Lucie Hájek, Roman Muthu Raja, Karthick Raja
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	141113
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00057825
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Regulatory T cells; multiple myeloma; dexamethasone; immune system (en)
http://linked.open.../riv/klicoveSlovo	dexamethasone immune system multiple myeloma Regulatory T cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1435529FE24B]
http://linked.open...i/riv/nazevZdroje	PLoS One
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Standardized flow cytometry as a toll for fast and sensitive diagnostics in hematology – implementation of the Euroflow protocols in Czech Republic Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Complex analysis of importance and pathogenesis of extramedullary relapse in patients with multiple myeloma
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Hájek, Roman Penka, Miroslav Říhová, Lucie Muthu Raja, Karthick Raja Klincová, Mária Zahradová, Lenka
http://linked.open...ain/vavai/riv/wos	000312385200077
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	1932-6203
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0047077
http://localhost/t...ganizacniJednotka	14110

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