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Description
| - Schisandra chinensis (Schisandraceae) is a well-known medicinal plant in traditional Chinese medicine. Recently was found that dibenzocyclooctadiene lignans inhibit ATP binding cassette (ABC) transporters, P-glycoprotein and multidrug resistance-associated protein 1 (MRP1), which export drugs out of the cancer cells. In our previous study, we have isolated nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gamma-schizandrin and wuweizisu C from seeds of Schisandra chinensis and lignans were examined for their effect on doxorubicin-resistant human lung carcinoma COR-L23/R cell line over-expressing MRP1. We have found that two lignans, R-(+)-deoxyschizandrin and R,S-gamma-schizandrin at relatively non-toxic concentrations enhanced the accumulation of doxorubicin in COR-L23/R cells and restored the cytotoxic action of doxorubicin on drug-resistant cells (Slaninová et al.: Toxicology in Vitro 23, 2009, 1047).
- Schisandra chinensis (Schisandraceae) is a well-known medicinal plant in traditional Chinese medicine. Recently was found that dibenzocyclooctadiene lignans inhibit ATP binding cassette (ABC) transporters, P-glycoprotein and multidrug resistance-associated protein 1 (MRP1), which export drugs out of the cancer cells. In our previous study, we have isolated nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gamma-schizandrin and wuweizisu C from seeds of Schisandra chinensis and lignans were examined for their effect on doxorubicin-resistant human lung carcinoma COR-L23/R cell line over-expressing MRP1. We have found that two lignans, R-(+)-deoxyschizandrin and R,S-gamma-schizandrin at relatively non-toxic concentrations enhanced the accumulation of doxorubicin in COR-L23/R cells and restored the cytotoxic action of doxorubicin on drug-resistant cells (Slaninová et al.: Toxicology in Vitro 23, 2009, 1047). (en)
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Title
| - Isolation of P-glycoprotein inhibitors from Schisandra chinensis
- Isolation of P-glycoprotein inhibitors from Schisandra chinensis (en)
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skos:prefLabel
| - Isolation of P-glycoprotein inhibitors from Schisandra chinensis
- Isolation of P-glycoprotein inhibitors from Schisandra chinensis (en)
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skos:notation
| - RIV/00216224:14110/12:00057525!RIV13-GA0-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/12:00057525
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - dibenzocyclooctadiene; promyelotic leukaemia cells; cancer; Schisandra chinensis; lignans; P-glycoprotein (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Slaninová, Iva
- Peš, Ondřej
- Páchniková, Gabriela
- Slanina, Jiří
- Čarnecká, Martina
- Vymazal, Ondřej
- Zemánková, Anežka
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http://localhost/t...ganizacniJednotka
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