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  • Schisandra chinensis (Schisandraceae) is a well-known medicinal plant in traditional Chinese medicine. Recently was found that dibenzocyclooctadiene lignans inhibit ATP binding cassette (ABC) transporters, P-glycoprotein and multidrug resistance-associated protein 1 (MRP1), which export drugs out of the cancer cells. In our previous study, we have isolated nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gamma-schizandrin and wuweizisu C from seeds of Schisandra chinensis and lignans were examined for their effect on doxorubicin-resistant human lung carcinoma COR-L23/R cell line over-expressing MRP1. We have found that two lignans, R-(+)-deoxyschizandrin and R,S-gamma-schizandrin at relatively non-toxic concentrations enhanced the accumulation of doxorubicin in COR-L23/R cells and restored the cytotoxic action of doxorubicin on drug-resistant cells (Slaninová et al.: Toxicology in Vitro 23, 2009, 1047).
  • Schisandra chinensis (Schisandraceae) is a well-known medicinal plant in traditional Chinese medicine. Recently was found that dibenzocyclooctadiene lignans inhibit ATP binding cassette (ABC) transporters, P-glycoprotein and multidrug resistance-associated protein 1 (MRP1), which export drugs out of the cancer cells. In our previous study, we have isolated nine dibenzo[a,c]cyclooctadiene lignans, schizandrin, gomisin A, gomisin N, gomisin J, angeloylgomisin H, tigloylgomisin P, deoxyschizandrin, gamma-schizandrin and wuweizisu C from seeds of Schisandra chinensis and lignans were examined for their effect on doxorubicin-resistant human lung carcinoma COR-L23/R cell line over-expressing MRP1. We have found that two lignans, R-(+)-deoxyschizandrin and R,S-gamma-schizandrin at relatively non-toxic concentrations enhanced the accumulation of doxorubicin in COR-L23/R cells and restored the cytotoxic action of doxorubicin on drug-resistant cells (Slaninová et al.: Toxicology in Vitro 23, 2009, 1047). (en)
Title
  • Isolation of P-glycoprotein inhibitors from Schisandra chinensis
  • Isolation of P-glycoprotein inhibitors from Schisandra chinensis (en)
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  • Isolation of P-glycoprotein inhibitors from Schisandra chinensis
  • Isolation of P-glycoprotein inhibitors from Schisandra chinensis (en)
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  • RIV/00216224:14110/12:00057525!RIV13-GA0-14110___
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  • P(GA522/07/0995)
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  • 143130
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  • RIV/00216224:14110/12:00057525
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  • dibenzocyclooctadiene; promyelotic leukaemia cells; cancer; Schisandra chinensis; lignans; P-glycoprotein (en)
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  • Slaninová, Iva
  • Peš, Ondřej
  • Páchniková, Gabriela
  • Slanina, Jiří
  • Čarnecká, Martina
  • Vymazal, Ondřej
  • Zemánková, Anežka
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  • 14110
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