About: Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Common variable immunodeficiency (CVID), the most frequent primary antibody disorder, is characterized by hypogammaglobulinaemia and impaired antibody production. Poor vaccination response is essential for the diagnosis of CVID. Their under laying defects remain to be elucidated. Routine determination of antibody production in serum from CVID patients after vaccination and investigation of B cell function in vivo is complicated due to substitution therapy. Therefore we investigated antibody production on the B-cell level by ELISPOT and characterized changes in B-cell subpopulations in CVID patients, including plasmablasts, in peripheral blood by flow cytometry after vaccination for specification of the diagnosis. Thirty-seven CVID patients and eighty healthy volunteers were immunized with tetanus toxoid and pneumococcal polysaccharide vaccines. Common variable immunodeficiency (CVID), the most frequent primary antibody disorder, is characterized by hypogammaglobulinaemia and impaired antibody production. Poor vaccination response is essential for the diagnosis of CVID. Their under laying defects remain to be elucidated. Routine determination of antibody production in serum from CVID patients after vaccination and investigation of B cell function in vivo is complicated due to substitution therapy. Therefore we investigated antibody production on the B-cell level by ELISPOT and characterized changes in B-cell subpopulations in CVID patients, including plasmablasts, in peripheral blood by flow cytometry after vaccination for specification of the diagnosis. Thirty-seven CVID patients and eighty healthy volunteers were immunized with tetanus toxoid and pneumococcal polysaccharide vaccines. (en)
Title	Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination (en)
skos:prefLabel	Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination Antibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination (en)
skos:notation	RIV/00216224:14110/11:00059060!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7E08062), P(NR9035)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vlková, Marcela Thon, Vojtěch Lokaj, Jindřich Chovancová, Zita Litzman, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	186419
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00059060
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CVID Tetanus toxoid Pneumococcal vaccine ELISPOT (en)
http://linked.open.../riv/klicoveSlovo	CVID Tetanus toxoid Pneumococcal vaccine ELISPOT
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[76926DFEC463]
http://linked.open...i/riv/nazevZdroje	Vaccine
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes Specific antibody response in patients with impaired immunity
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Chovancová, Zita Litzman, Jiří Lokaj, Jindřich Thon, Vojtěch Vlková, Marcela
http://linked.open...ain/vavai/riv/wos	000292176800010
issn	0264-410X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.vaccine.2011.03.087
http://localhost/t...ganizacniJednotka	14110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software