About: Tubal ligation and the risk of ovarian cancer: review and meta-analysis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	background: The reduction of ovarian cancer (OC) risk in women with a history of tubal ligation (TL) has been reported repeatedly, mostly on small populations. We have aimed to provide a critical overview of the studies available to date and to conduct a meta-analysis. results: Meta-analysis of 13 strictly selected studies showed a reduced risk of epithelial OC by 34%. The protective effect of TL was confirmed even in a subgroup of women 10–14 years after the procedure. The risk reduction was confirmed for the endometrioid (RR = 0.40) and serous (RR = 0.73) cancers but not for mucinous. conclusions: The review of relevant articles, as well as the meta-analysis of selected studies, yields consistent data on a significant reduction of OC risk in women who had undergone TL. The results of this meta-analysis should provide an impulse for further research on the etiology of ovarian epithelial cancers, focusing particularly on the importance of retrograde transport of endometrial cells. background: The reduction of ovarian cancer (OC) risk in women with a history of tubal ligation (TL) has been reported repeatedly, mostly on small populations. We have aimed to provide a critical overview of the studies available to date and to conduct a meta-analysis. results: Meta-analysis of 13 strictly selected studies showed a reduced risk of epithelial OC by 34%. The protective effect of TL was confirmed even in a subgroup of women 10–14 years after the procedure. The risk reduction was confirmed for the endometrioid (RR = 0.40) and serous (RR = 0.73) cancers but not for mucinous. conclusions: The review of relevant articles, as well as the meta-analysis of selected studies, yields consistent data on a significant reduction of OC risk in women who had undergone TL. The results of this meta-analysis should provide an impulse for further research on the etiology of ovarian epithelial cancers, focusing particularly on the importance of retrograde transport of endometrial cells. (en)
Title	Tubal ligation and the risk of ovarian cancer: review and meta-analysis Tubal ligation and the risk of ovarian cancer: review and meta-analysis (en)
skos:prefLabel	Tubal ligation and the risk of ovarian cancer: review and meta-analysis Tubal ligation and the risk of ovarian cancer: review and meta-analysis (en)
skos:notation	RIV/00216224:14110/11:00056956!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NS10621), V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Májek, Ondřej Dušek, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	236177
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00056956
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tubal ligation; BRCA mutation; ovarian cancer; meta-analysis (en)
http://linked.open.../riv/klicoveSlovo	BRCA mutation tubal ligation meta-analysis ovarian cancer
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D8A0DD2BC7A1]
http://linked.open...i/riv/nazevZdroje	Human Reproduction Update
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Optimalization of Clinical Information Acquisition from Medical Registries
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Cibula, David Dušek, Ladislav Májek, Ondřej Widschwendter, M.
http://linked.open...ain/vavai/riv/wos	000285415400006
issn	1355-4786
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/humupd/dmq030
http://localhost/t...ganizacniJednotka	14110

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