About: MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications. MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications. (en)
Title	MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications (en)
skos:prefLabel	MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications (en)
skos:notation	RIV/00216224:14110/11:00055225!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita	I P S V Z
http://linked.open...avai/riv/aktivity	I, P(NT11214), S, V, Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Šána, Jiří Michálek, Jaroslav Vyzula, Rostislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	212338
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00055225
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glioblastoma; microRNAs; prognosis; prediction; therapeutic targets (en)
http://linked.open.../riv/klicoveSlovo	microRNAs glioblastoma prediction prognosis therapeutic targets
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[59E49865A061]
http://linked.open...i/riv/nazevZdroje	Journal of Cellular and Molecular Medicine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Slabý, Ondřej Šána, Jiří Vyzula, Rostislav Hajdúch, Marian
http://linked.open...ain/vavai/riv/wos	000292700800002
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1582-1838
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1582-4934.2011.01317.x
http://localhost/t...ganizacniJednotka	14110

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