About: Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients

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About: Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bortezomib induced peripheral neuropathy is a dose-limiting side effect and a major concern in the treatment of multiple myeloma. To identify genetic risk factors associated with the development of this side effect in bortezomib treated multiple myeloma patients, a pharmacogenetic association study was performed using a discovery set (IFM 2005-01; n=238) and a validation set (HOVON65/GMMG-HD4 and a Czech dataset; n=231). After multiplicity correction, none of the 2,149 single nucleotide polymorphisms tested revealed any significant association with bortezomib induced peripheral neuropathy. However, 56 single nucleotide polymorphisms demonstrated an association with bortezomib induced peripheral neuropathy with pointwise, uncorrected significance. Pathway analysis of these polymorphisms demonstrated involvement of neurological disease (FDR <20%). Also a clear enrichment of major bortezomib metabolizing genes was found. Bortezomib induced peripheral neuropathy is a dose-limiting side effect and a major concern in the treatment of multiple myeloma. To identify genetic risk factors associated with the development of this side effect in bortezomib treated multiple myeloma patients, a pharmacogenetic association study was performed using a discovery set (IFM 2005-01; n=238) and a validation set (HOVON65/GMMG-HD4 and a Czech dataset; n=231). After multiplicity correction, none of the 2,149 single nucleotide polymorphisms tested revealed any significant association with bortezomib induced peripheral neuropathy. However, 56 single nucleotide polymorphisms demonstrated an association with bortezomib induced peripheral neuropathy with pointwise, uncorrected significance. Pathway analysis of these polymorphisms demonstrated involvement of neurological disease (FDR <20%). Also a clear enrichment of major bortezomib metabolizing genes was found. (en)
Title	Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients (en)
skos:prefLabel	Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients (en)
skos:notation	RIV/00216224:14110/11:00054780!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06027), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	200997
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00054780
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bortezomib; peripheral neuropathy; risk; single nucleotide polymorphism (en)
http://linked.open.../riv/klicoveSlovo	single nucleotide polymorphism bortezomib peripheral neuropathy risk
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[CC2972E55E16]
http://linked.open...i/riv/nazevZdroje	Haematologica/the hematology journal
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	University Research Centre - Czech Myeloma Group
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	96
http://linked.open...iv/tvurceVysledku	Hájek, Roman Avet-Loiseau, H. Corthals, S. L. Goldschmidt, H. Johnson, D. C. Kuiper, R. Magrangeas, F. Morgan, G. J. Sonneveld, P. van der Holt, B.
http://linked.open...ain/vavai/riv/wos	000297243800027
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0390-6078
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.3324/haematol.2011.041434
http://localhost/t...ganizacniJednotka	14110

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