About: Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

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About: Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres. These events consist of cellular and molecular alterations, including macrophage invasion, activation of Schwann cells, as well as neurotrophin and cytokine upregulation. This review focuses on cellular and molecular changes distal to various types of peripheral nerve injury which simultaneously contribute to axonal regeneration and neuropathic pain induction. In addition to the stereotypical events of Wallerian degeneration, various types of nerve damage provide different conditions for both axonal regeneration and neuropathic pain induction. Wallerian degeneration of injured peripheral nerve is associated with an inflammatory response including rapid upregulation of the immune signal molecules like cytokines, chemokines and transcription factors with both beneficial and detrimental effects on nerve regeneration or neuropathic pain induction. Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres. These events consist of cellular and molecular alterations, including macrophage invasion, activation of Schwann cells, as well as neurotrophin and cytokine upregulation. This review focuses on cellular and molecular changes distal to various types of peripheral nerve injury which simultaneously contribute to axonal regeneration and neuropathic pain induction. In addition to the stereotypical events of Wallerian degeneration, various types of nerve damage provide different conditions for both axonal regeneration and neuropathic pain induction. Wallerian degeneration of injured peripheral nerve is associated with an inflammatory response including rapid upregulation of the immune signal molecules like cytokines, chemokines and transcription factors with both beneficial and detrimental effects on nerve regeneration or neuropathic pain induction. (en)
Title	Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction (en)
skos:prefLabel	Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction (en)
skos:notation	RIV/00216224:14110/11:00053051!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Dubový, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	241487
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00053051
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nerve injury; Activated Schwann cells; Macrophages; Neuroinflammation; Neurotrophins; Cytokines; Chemokines (en)
http://linked.open.../riv/klicoveSlovo	Activated Schwann cells Chemokines Neurotrophins Macrophages Cytokines Nerve injury Neuroinflammation
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[AE5B062DA62F]
http://linked.open...i/riv/nazevZdroje	Annals of Anatomy
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	193
http://linked.open...iv/tvurceVysledku	Dubový, Petr
http://linked.open...ain/vavai/riv/wos	000294520800004
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0940-9602
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.aanat.2011.02.011
http://localhost/t...ganizacniJednotka	14110

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