About: Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma. Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma. (en)
Title	Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients (en)
skos:prefLabel	Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients (en)
skos:notation	RIV/00216224:14110/11:00050101!RIV12-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(LC06027), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šváchová, Hana Pour, Luděk Šána, Jiří Říhová, Lucie Hájek, Roman Muthu Raja, Karthick Raja
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	232342
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00050101
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nestin; Plasma cells; Multiple myeloma; Myeloma stem cells; Flow cytometry (en)
http://linked.open.../riv/klicoveSlovo	Myeloma stem cells Nestin Plasma cells Multiple myeloma Flow cytometry
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EF51850E0CCA]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies University Research Centre - Czech Myeloma Group
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Hájek, Roman Pour, Luděk Říhová, Lucie Šána, Jiří Šváchová, Hana Muthu Raja, Karthick Raja
http://linked.open...ain/vavai/riv/wos	000292735300007
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0145-2126
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.leukres.2011.03.001
http://localhost/t...ganizacniJednotka	14110

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