About: Association of aneuploidy category with centrosome amplification in multiple myeloma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development. Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development. (en)
Title	Association of aneuploidy category with centrosome amplification in multiple myeloma Association of aneuploidy category with centrosome amplification in multiple myeloma (en)
skos:prefLabel	Association of aneuploidy category with centrosome amplification in multiple myeloma Association of aneuploidy category with centrosome amplification in multiple myeloma (en)
skos:notation	RIV/00216224:14110/11:00050008!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(LC06027), P(NS10207), P(NS10406), P(NS10408), P(NT11154), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kryukov, Fedor Smetana, Jan Ševčíková, Sabina Dementyeva, Elena Vladimirovna Kuglík, Petr Hájek, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	187324
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00050008
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; centrosome amplification; plasma cell; B-cell; hyperdiploid (en)
http://linked.open.../riv/klicoveSlovo	B-cell centrosome amplification hyperdiploid plasma cell multiple myeloma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B87589EB6552]
http://linked.open...i/riv/nazevZdroje	Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies University Research Centre - Czech Myeloma Group Creating of prognostic panel in patients with monoclonal gammopathy of undetermined significance with a target to prevent the risk of malignant transformation. Phenotype feature of B cells and plasma cells and its association with malignant transformation in monoclonal gammopathies
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Dementyeva, Elena Vladimirovna Hájek, Roman Kuglík, Petr Kryukov, Fedor Smetana, Jan Ševčíková, Sabina
http://linked.open...ain/vavai/riv/wos	000295176800030
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	1042-8194
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2011.587561
http://localhost/t...ganizacniJednotka	14110

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