About: Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is a hematological disease caused by malignant proliferation of clonal plasma cells (PCs) known for its clinical and biological heterogeneity. Identification of chromosomal changes in genome of PCs plays a key role in MM pathogenesis and is supposed to have important prognostic significance for MM patients. There are two major genetic entities in MM. Hyperdiploid tumors (H-MM), which include about 50% of MM tumors, often have multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15, 19, and 21 and a substantially lower prevalence of IgH translocations. Nearly half of tumors are non-hyperdiploid (NH-MM), and mostly have one of five recurrent IgH translocations: 11q13 (CCND1), 6p21 (CCND3), 16q23 (MAF), 20q12 (MAFB), and 4p16 (FGFR3 and MMSET). The development and expanded use of new technologies, such as genome-wide array-based comparative genomic hybridization (aCGH) has accelerated genomic research in MM. Multiple myeloma (MM) is a hematological disease caused by malignant proliferation of clonal plasma cells (PCs) known for its clinical and biological heterogeneity. Identification of chromosomal changes in genome of PCs plays a key role in MM pathogenesis and is supposed to have important prognostic significance for MM patients. There are two major genetic entities in MM. Hyperdiploid tumors (H-MM), which include about 50% of MM tumors, often have multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15, 19, and 21 and a substantially lower prevalence of IgH translocations. Nearly half of tumors are non-hyperdiploid (NH-MM), and mostly have one of five recurrent IgH translocations: 11q13 (CCND1), 6p21 (CCND3), 16q23 (MAF), 20q12 (MAFB), and 4p16 (FGFR3 and MMSET). The development and expanded use of new technologies, such as genome-wide array-based comparative genomic hybridization (aCGH) has accelerated genomic research in MM. (en)
Title	Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients (en)
skos:prefLabel	Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients (en)
skos:notation	RIV/00216224:14110/11:00049842!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(LC06027), P(NS10207), P(NS10406), P(NS10408), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Smetana, Jan Hájek, Roman Mikulášová, Aneta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	217889
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00049842
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; array-CGH; cytogenetics (en)
http://linked.open.../riv/klicoveSlovo	multiple myeloma array-CGH cytogenetics
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0BBD8D28D798]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies University Research Centre - Czech Myeloma Group Creating of prognostic panel in patients with monoclonal gammopathy of undetermined significance with a target to prevent the risk of malignant transformation. Phenotype feature of B cells and plasma cells and its association with malignant transformation in monoclonal gammopathies
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kuglík, Petr Smetana, Jan Vranová, Vladimíra Mikulášová, Aneta Fröhlich, Jan
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0862-495X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software