About: Sample Processing and Methodological Pitfalls in Multiple Myeloma Research

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this paper, initial processing of biological material, cell separation algorithms and other procedures are discussed. For samples with initial infiltration of plasma cells > 5%, CD138 MicroBeads and Auto-Magnetic-Activated Cell Sorting program are used. Fluorescence-Activated Cell Sorting is used exclusively for cell populations with low-abundance; these samples are detected using fluorescently labeled antibodies only. Isolated plasma cells are further processed for molecular biological studies, for cytogenetics and protein analyses. Furthermore, this work examines the pitfalls of research related to multiple myeloma; some of them we have overcome, while the others are still problematic. In this paper, initial processing of biological material, cell separation algorithms and other procedures are discussed. For samples with initial infiltration of plasma cells > 5%, CD138 MicroBeads and Auto-Magnetic-Activated Cell Sorting program are used. Fluorescence-Activated Cell Sorting is used exclusively for cell populations with low-abundance; these samples are detected using fluorescently labeled antibodies only. Isolated plasma cells are further processed for molecular biological studies, for cytogenetics and protein analyses. Furthermore, this work examines the pitfalls of research related to multiple myeloma; some of them we have overcome, while the others are still problematic. (en)
Title	Sample Processing and Methodological Pitfalls in Multiple Myeloma Research Sample Processing and Methodological Pitfalls in Multiple Myeloma Research (en)
skos:prefLabel	Sample Processing and Methodological Pitfalls in Multiple Myeloma Research Sample Processing and Methodological Pitfalls in Multiple Myeloma Research (en)
skos:notation	RIV/00216224:14110/11:00049835!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(GP301/09/P457), P(LC06027), P(NS10207), P(NS10387), P(NS10406), P(NS10408), P(NT11154), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Říhová, Lucie Hájek, Roman Bartoňová, Jana Potáčová, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	228124
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00049835
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; monoclonal gammopathy; cell separation; CD138 (en)
http://linked.open.../riv/klicoveSlovo	CD138 cell separation multiple myeloma monoclonal gammopathy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[21110F5CA32A]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Multiparametric flow cytometry in study of malignant plasma cells pathophysiology Assessment of free light chains as auxiliary marker for the evaluation of prognosis and of the response to treatment in patients with multiple myeloma and with monoclonal gammopathy of unknown significance Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies University Research Centre - Czech Myeloma Group Creating of prognostic panel in patients with monoclonal gammopathy of undetermined significance with a target to prevent the risk of malignant transformation. Phenotype feature of B cells and plasma cells and its association with malignant transformation in monoclonal gammopathies
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Almáši, Martina Bartoňová, Jana Burešová, I. Hájek, Roman Penka, Miroslav Říhová, Lucie Potáčová, Anna
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0862-495X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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