About: Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monoclonal gammopathy of undetermined significance (MGUS) is a precancerosis comprising two different kinds of cancer: lymphoid/lymphoplasmocytoid MGUS and plasma cell MGUS that represents about 85% of all MGUS cases. This type of MGUS has low but persistent tendency to transform to malignant disease, mainly multiple myeloma (MM), with frequency of about 1% per year. Using known risk stratification models based on clinical parameters, it is possible to identify patients’ groups with average rates of progression as low as 0.26% and as high as 12% per year. However, due to the lack of clear genetic and/or phenotypic markers distinguishing MGUS from MM, we are not able to predict if and when MGUS will progress to MM in individual patients. There are partially overlapping molecular pathogenic events shared by MGUS and MM. Monoclonal gammopathy of undetermined significance (MGUS) is a precancerosis comprising two different kinds of cancer: lymphoid/lymphoplasmocytoid MGUS and plasma cell MGUS that represents about 85% of all MGUS cases. This type of MGUS has low but persistent tendency to transform to malignant disease, mainly multiple myeloma (MM), with frequency of about 1% per year. Using known risk stratification models based on clinical parameters, it is possible to identify patients’ groups with average rates of progression as low as 0.26% and as high as 12% per year. However, due to the lack of clear genetic and/or phenotypic markers distinguishing MGUS from MM, we are not able to predict if and when MGUS will progress to MM in individual patients. There are partially overlapping molecular pathogenic events shared by MGUS and MM. (en)
Title	Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues (en)
skos:prefLabel	Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues (en)
skos:notation	RIV/00216224:14110/11:00049834!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1395), P(LC06027), P(NS10387), P(NS10406), P(NS10408), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Roman Mikulášová, Aneta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	213659
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00049834
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	monoclonal gammopathy of undeterminated significance; multiple myeloma; progression; molecular-genetic approach (en)
http://linked.open.../riv/klicoveSlovo	progression molecular-genetic approach monoclonal gammopathy of undeterminated significance multiple myeloma
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3E3FE9EFF89B]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Assessment of free light chains as auxiliary marker for the evaluation of prognosis and of the response to treatment in patients with multiple myeloma and with monoclonal gammopathy of unknown significance Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies University Research Centre - Czech Myeloma Group Creating of prognostic panel in patients with monoclonal gammopathy of undetermined significance with a target to prevent the risk of malignant transformation. Phenotype feature of B cells and plasma cells and its association with malignant transformation in monoclonal gammopathies
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Hájek, Roman Maisnar, V. Klincová, Mária Mikulášová, Aneta Radocha, J. Sandecká, Viera
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0862-495X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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