About: Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA

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About: Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Serial quantitation of BCR-ABL mRNA levels is an important indicator of therapeutic response for patients with chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia, but there is substantial variation in the real-time quantitative polymerase chain reaction methodologies used by different testing laboratories. To help improve the comparability of results between centers we sought to develop accredited reference reagents that are directly linked to the BCR-ABL international scale. After assessment of candidate cell lines, a reference material panel comprising 4 different dilution levels of freeze-dried preparations of K562 cells diluted in HL60 cells was prepared. After performance evaluation, the materials were assigned fixed percent BCR-ABL/control gene values according to the International Scale. Serial quantitation of BCR-ABL mRNA levels is an important indicator of therapeutic response for patients with chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia, but there is substantial variation in the real-time quantitative polymerase chain reaction methodologies used by different testing laboratories. To help improve the comparability of results between centers we sought to develop accredited reference reagents that are directly linked to the BCR-ABL international scale. After assessment of candidate cell lines, a reference material panel comprising 4 different dilution levels of freeze-dried preparations of K562 cells diluted in HL60 cells was prepared. After performance evaluation, the materials were assigned fixed percent BCR-ABL/control gene values according to the International Scale. (en)
Title	Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA (en)
skos:prefLabel	Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA (en)
skos:notation	RIV/00216224:14110/10:00058936!RIV13-MSM-14110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dvořáková, Dana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	257518
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00058936
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	World Health Organization International Genetic Reference Panel; BCR-ABL (en)
http://linked.open.../riv/klicoveSlovo	BCR-ABL World Health Organization International Genetic Reference Panel
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BE18AC58048D]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	31 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	116
http://linked.open...iv/tvurceVysledku	Dvořáková, Dana Wang, L. Metcalfe, P. Müller, Martin Jones, D. Saglio, G. Beaufils, Nathalie Beillard, Emmanuel Branford, Susan Colomer, Dolors Cross, N.C.P. Ehrencrona, Hans El Housni, H. Gabert, Jean Goh, Hyun-Gyung Goldman, J. M. Hochhaus, A. Hughes, T. Kairisto, V. Kamel-Reid, S. Kim, Dong-Wook Langabeer, S. Lin, Feng Ma, Edmond S. K. Matejtschuk, Paul Press, R. D. Rigsby, Peter Romeo, G. Wang, YL White, Helen Zoi, K.
http://linked.open...ain/vavai/riv/wos	000284599900002
issn	0006-4971
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2010-06-291641
http://localhost/t...ganizacniJednotka	14110

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