About: Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study

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About: Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple sclerosis is a disease with considerable individual variation, and genetic background plays a key role in disease susceptibility and severity. The objective of the study was to evaluate the relationship between apolipoprotein E (APOE) genotype and the evolution of different clinical and MRI parameters. We investigated a group of 150 relapsing-remitting patients that completed 4-year follow-up. The mean age was 30.2 years, disease duration 56.8 months, and baseline Expanded Disability Status Scale (EDSS) 1.8. The changes in brain parenchymal volume (BPV), gray matter (GMV), white matter (WMV) and peripheral gray volume (PGMV) were measured by SIENA/X. T2-lesion volume was assessed by semi-automated methods. The mixed-effect model analysis was used to investigate evolution of clinical and MRI parameters in relation to the APOE epsilon 4 genotype considering two different time models: 4-year follow-up and 15-year period from disease onset. We identified 36 APOE epsilon 4-positive patients. Multiple sclerosis is a disease with considerable individual variation, and genetic background plays a key role in disease susceptibility and severity. The objective of the study was to evaluate the relationship between apolipoprotein E (APOE) genotype and the evolution of different clinical and MRI parameters. We investigated a group of 150 relapsing-remitting patients that completed 4-year follow-up. The mean age was 30.2 years, disease duration 56.8 months, and baseline Expanded Disability Status Scale (EDSS) 1.8. The changes in brain parenchymal volume (BPV), gray matter (GMV), white matter (WMV) and peripheral gray volume (PGMV) were measured by SIENA/X. T2-lesion volume was assessed by semi-automated methods. The mixed-effect model analysis was used to investigate evolution of clinical and MRI parameters in relation to the APOE epsilon 4 genotype considering two different time models: 4-year follow-up and 15-year period from disease onset. We identified 36 APOE epsilon 4-positive patients. (en)
Title	Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study (en)
skos:prefLabel	Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study (en)
skos:notation	RIV/00216224:14110/10:00051731!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P S V Z
http://linked.open...avai/riv/aktivity	I, P(1A8713), S, V, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kýr, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	247354
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051731
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple sclerosis; APOE; brain atrophy; gray matter; MRI; mixed-effect model (en)
http://linked.open.../riv/klicoveSlovo	gray matter mixed-effect model MRI multiple sclerosis brain atrophy APOE
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B1FBA462CA1D]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Pharmacogenomics - a promising way for reasonable and efficacious multiple sclerosis treatment
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Seidl, Z. Vaneckova, M. Havrdová, E. Horáková, D. Bergsland, N. Dwyer, M. G. Hussein, S. Kýr, Michal Cox, J. L. Doležal, O. Krasensky, J. Lelková, P. Pospisilová, L. Zivadinov, R.
http://linked.open...ain/vavai/riv/wos	000286039500002
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0015-5500
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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