About: Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughout the study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation. During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughout the study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation. (en)
Title	Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients (en)
skos:prefLabel	Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients (en)
skos:notation	RIV/00216224:14110/10:00051729!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kýr, Michal Fedora, Michal Ševčík, Pavel Michálek, Jaroslav Šrámek, Vladimír Maláska, Jan Otevřel, Filip Kratochvíl, Milan Jabandžiev, Petr Muriová, Katarína
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	252649
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051729
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sepsis; multiorgan failure; Cytokines; CRP; PCT; TREM-1; IL-6; IL-12; IL-4; IL-1 beta; TNF (en)
http://linked.open.../riv/klicoveSlovo	IL-1 beta IL-6 multiorgan failure sepsis IL-12 CRP Cytokines TNF TREM-1 IL-4 PCT
http://linked.open...ontrolniKodProRIV	[01D81DFDF2F3]
http://linked.open...v/mistoKonaniAkce	Munich, Germany
http://linked.open...i/riv/mistoVydani	Philadelphia
http://linked.open...i/riv/nazevZdroje	Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Fedora, Michal Michálek, Jaroslav Ševčík, Pavel Šrámek, Vladimír Maláska, Jan Kýr, Michal Jabandžiev, Petr Kratochvíl, Milan Muriová, Katarína Otevřel, Filip
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000281967800007
http://linked.open.../riv/zahajeniAkce	2010-03-09 (xsd:date)
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Thomson Reuters
https://schema.org/isbn	978-88-6521-024-6
http://localhost/t...ganizacniJednotka	14110

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