About: MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients

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About: MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies showed altered expression levels of several microRNAs in glioblastomas. In this study, we examined the expression levels of selected microRNAs in 22 primary glioblastomas and six specimens of adult brain tissue by real-time PCR method. In addition, we examined methylation status of MGMT promoter by methylation-specific real-time PCR, as this has been shown to be a predictive marker in glioblastomas. MGMT methylation status was not correlated with response to concomitant chemoradiotherapy with temozolomide (RT/TMZ). MiR-221 (p=0,016), miR-222 (p=0,038), miR-181b (p=0,036), miR-181c (p=0,043) and miR-128a (p=0,001) were significantly down-regulated in glioblastomas. The most significant change was observed for up-regulation in miR-21 expression in glioblastomas (p<0,001). MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies showed altered expression levels of several microRNAs in glioblastomas. In this study, we examined the expression levels of selected microRNAs in 22 primary glioblastomas and six specimens of adult brain tissue by real-time PCR method. In addition, we examined methylation status of MGMT promoter by methylation-specific real-time PCR, as this has been shown to be a predictive marker in glioblastomas. MGMT methylation status was not correlated with response to concomitant chemoradiotherapy with temozolomide (RT/TMZ). MiR-221 (p=0,016), miR-222 (p=0,038), miR-181b (p=0,036), miR-181c (p=0,043) and miR-128a (p=0,001) were significantly down-regulated in glioblastomas. The most significant change was observed for up-regulation in miR-21 expression in glioblastomas (p<0,001). (en)
Title	MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients (en)
skos:prefLabel	MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients (en)
skos:notation	RIV/00216224:14110/10:00051702!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(NS9875), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Nováková, Jana Valík, Dalibor Křen, L. Smrčka, Martin Michálek, Jaroslav Vyzula, Rostislav Svoboda, Marek Fadrus, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	271243
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051702
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; MGMT methylation; glioblastoma; chemoradiotherapy; temozolomide (en)
http://linked.open.../riv/klicoveSlovo	temozolomide glioblastoma chemoradiotherapy MGMT methylation microRNA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8EADABA5D5FE]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of immunoresistance in glioblastoma
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Michálek, Jaroslav Nováková, Jana Slabý, Ondřej Valík, Dalibor Křen, Leoš Lžičařová, Eva Smrčka, Martin Svoboda, Marek Vyzula, Rostislav Fadrus, Pavel Doležalová, H. Lakomý, Roman
http://linked.open...ain/vavai/riv/wos	000277412800012
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	0028-2685
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2010_03_264
http://localhost/t...ganizacniJednotka	14110

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