About: A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome

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About: A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS. Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS. (en)
Title	A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome (en)
skos:prefLabel	A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome (en)
skos:notation	RIV/00216224:14110/10:00051564!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(NR9235), P(NS9634), V, Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Budinská, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	244593
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051564
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells (en)
http://linked.open.../riv/klicoveSlovo	Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D9C01506D594]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Determination of SNP and DNA methylation profiles in patients with myelodysplatic syndrome by microarrays. INVESTIGATION OF GENE EXPRESSION PROFILING IN PATIENTS WITH MYELODYSPLASTIC SYNDROME
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Beličková, Monika Čermák, Jaroslav Budinská, Eva Vašíková, Alžbeta
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0145-2126
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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