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  • Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile).
  • Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile). (en)
Title
  • Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
  • Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes (en)
skos:prefLabel
  • Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
  • Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes (en)
skos:notation
  • RIV/00216224:14110/10:00051512!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z20760514), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 255971
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/10:00051512
http://linked.open...riv/jazykVysledku
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  • ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E7FDF70E87C6]
http://linked.open...i/riv/nazevZdroje
  • Acta Physiologica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 200
http://linked.open...iv/tvurceVysledku
  • Bébarová, Markéta
  • Pásek, Michal
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Jansová, Dagmar
  • Matejovič, Peter
  • Ohlídalová, Dana
http://linked.open...ain/vavai/riv/wos
  • 000284810500002
http://linked.open...n/vavai/riv/zamer
issn
  • 1748-1708
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/j.1748-1716.2010.02162.x
http://localhost/t...ganizacniJednotka
  • 14110
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