About: Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis.

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About: Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have evaluated the contribution of 1,3-ß-D-glucan (BG) assay for screening of invasive fungal diseases (IFI) in patients with hematological malignancies. Serum samples from patients at risk of IFI were collected twice a week and retrospectively tested using the BG assay. BG screening was performed on 1143 samples from 91 patients during 104 anticancer treatment cycles. Proven and probable cases of IFI occurred in 9 (8.7%) treatment cycles. Depending on the criterion of positivity used (1> 60 or 1> 80 pg/ml and 2> 60 or 2> 80 pg/ml) the sensitivity was 89%, 89%, 67% and 44%. Although the test was marked as positive in 82%, 68%, 54% and 45% of all the treatment cycles, in the majority of cases, these positivities were probably false. The major limit of the BG test was extremely low PPV (10% to 12%). We have analyzed mucositis, candida colonization, bacteremia, using antimicrobials, erythrocyte and thrombocyte filtered blood products, collecting tubes or sampling via venous catheters. We have evaluated the contribution of 1,3-ß-D-glucan (BG) assay for screening of invasive fungal diseases (IFI) in patients with hematological malignancies. Serum samples from patients at risk of IFI were collected twice a week and retrospectively tested using the BG assay. BG screening was performed on 1143 samples from 91 patients during 104 anticancer treatment cycles. Proven and probable cases of IFI occurred in 9 (8.7%) treatment cycles. Depending on the criterion of positivity used (1> 60 or 1> 80 pg/ml and 2> 60 or 2> 80 pg/ml) the sensitivity was 89%, 89%, 67% and 44%. Although the test was marked as positive in 82%, 68%, 54% and 45% of all the treatment cycles, in the majority of cases, these positivities were probably false. The major limit of the BG test was extremely low PPV (10% to 12%). We have analyzed mucositis, candida colonization, bacteremia, using antimicrobials, erythrocyte and thrombocyte filtered blood products, collecting tubes or sampling via venous catheters. (en)
Title	Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. (en)
skos:prefLabel	Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. (en)
skos:notation	RIV/00216224:14110/10:00051485!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS10441), P(NS10442), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Burešová, Lucie Kocmanová, I. Tošková, Martina Ráčil, Z. Lengerová, Martina Mayer, Jiří Winterová, Jana Timilsina, Shira
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	254393
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051485
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	invasive fungal disease; glucan; false positive results (en)
http://linked.open.../riv/klicoveSlovo	glucan invasive fungal disease false positive results
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DEA1255F903F]
http://linked.open...i/riv/nazevZdroje	Journal of Medical Microbiology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Monitoring of voriconazole plasma levels Importance of non-culture methods for diagnostics of invasive fungal infections caused by filamentous fungi from bronchoalveolar lavage fluid in hematooncological patients
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Burešová, Lucie Lengerová, Martina Mayer, Jiří Ráčil, Zdeněk Tošková, Martina Kocmanová, Iva Weinbergerová, Barbora Winterová, Jana Timilsina, Shira Rodriguez, Isa
http://linked.open...ain/vavai/riv/wos	000282117000003
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0022-2615
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/jmm.0.019299-0
http://localhost/t...ganizacniJednotka	14110

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