About: Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). (en)
Title	Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre (en)
skos:prefLabel	Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre (en)
skos:notation	RIV/00216224:14110/10:00051417!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10398)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pavlík, Tomáš Thon, Vojtěch Lokaj, Jindřich Litzman, Jiří Kuklínek, Pavel Pešák, Sáva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	250266
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051417
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins (en)
http://linked.open.../riv/klicoveSlovo	Common variable immunodeficiency Immunoglobulins X-linked agammaglobulinaemia
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[9DF96BA29E35]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	153
http://linked.open...iv/tvurceVysledku	Litzman, Jiří Lokaj, Jindřich Pavlík, Tomáš Thon, Vojtěch Kuklínek, Pavel Pešák, Sáva Pikulová, Zdenka Štikarovská, Dagmar
http://linked.open...ain/vavai/riv/wos	000279595800012
issn	1018-2438
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000301584
http://localhost/t...ganizacniJednotka	14110

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