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Description
| - Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient).
- Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). (en)
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Title
| - Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
- Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre (en)
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skos:prefLabel
| - Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
- Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre (en)
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skos:notation
| - RIV/00216224:14110/10:00051417!RIV12-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/10:00051417
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Litzman, Jiří
- Lokaj, Jindřich
- Pavlík, Tomáš
- Thon, Vojtěch
- Kuklínek, Pavel
- Pešák, Sáva
- Pikulová, Zdenka
- Štikarovská, Dagmar
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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