About: Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here, we demonstrate the derivation of highly enriched and expandable populations of proliferating neural precursors from the CCTL14 line of human embryonic stem cells (hESCs). These neural precursors could differentiate in vitro into functionally active neurons, as confirmed by immunohistochemical staining and electrophysiological analysis. Neural cells differentiated in vitro from hESCs exhibit broad cellular heterogeneity with respect to developmental stage and lineage specification. The analyzed cells were used for transplantation into the injured rodent brain; the tumorigenicity of the transplanted cells was apparently eliminated following long-term culture. These results complete the characterization of the CCTL14 line of hESCs and provide a framework for developing cell selection strategies for neural cell-based therapies.. Here, we demonstrate the derivation of highly enriched and expandable populations of proliferating neural precursors from the CCTL14 line of human embryonic stem cells (hESCs). These neural precursors could differentiate in vitro into functionally active neurons, as confirmed by immunohistochemical staining and electrophysiological analysis. Neural cells differentiated in vitro from hESCs exhibit broad cellular heterogeneity with respect to developmental stage and lineage specification. The analyzed cells were used for transplantation into the injured rodent brain; the tumorigenicity of the transplanted cells was apparently eliminated following long-term culture. These results complete the characterization of the CCTL14 line of hESCs and provide a framework for developing cell selection strategies for neural cell-based therapies.. (en)
Title	Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors (en)
skos:prefLabel	Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors Analysis of in vitro and in vivo characteristics of human embryonic stem cell-derived neural precursors (en)
skos:notation	RIV/00216224:14110/10:00051282!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0538), P(GA305/09/0717), P(GD309/08/H079), P(LC554), Z(AV0Z50390703), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hampl, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	246410
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051282
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human embryonic stem cells; neural differentiation; fluorescent activated cell sorting; RT-PCR; transplantation (en)
http://linked.open.../riv/klicoveSlovo	transplantation RT-PCR fluorescent activated cell sorting neural differentiation human embryonic stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[586181263C73]
http://linked.open...i/riv/nazevZdroje	Cell Transplantation
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	PhD program in neuroscience Center for Cell Therapy and Tissue Repair Neuroscience Centre Induction of neuro- and gliogenesis in rat brain after ischemia - the role of morphogenes and growth factors in the nervous tissue regeneration.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Hampl, Aleš Kubista, Mikael Syková, Eva Jendelová, Pavla Turnovcová, Karolína Anděrová, Miroslava Butenko, Olena Kapcalova, Miroslava Kozubenko, Nataliya Rusnáková, Vendula
http://linked.open...ain/vavai/riv/wos	000278942800009
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Establishing of the Biotechnology Institute ASCR
issn	0963-6897
number of pages	16 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software