About: Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. (en)
Title	Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL (en)
skos:prefLabel	Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL (en)
skos:notation	RIV/00216224:14110/10:00051241!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Doubek, Michael Mayer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	289992
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00051241
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	auto transplant; ALL; minimal residual disease (en)
http://linked.open.../riv/klicoveSlovo	ALL minimal residual disease auto transplant
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4F47EB718EE6]
http://linked.open...i/riv/nazevZdroje	Bone Marrow Transplantation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Doubek, Michael Mayer, Jiří Dombret, H. Giebel, S. Gökbuget, N. Hoelzer, D. Piccaluga, P. P. Ribera, J. M. Czerw, T. Holowiecki, J. Krawczyk-Kulis, M. Kyrcz-Krzemien, S. Piatkowska-Jakubas, B. Skotnicki, A. B. Stella-Holowiecka, B.
http://linked.open...ain/vavai/riv/wos	000278573600021
issn	0268-3369
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/bmt.2009.308
http://localhost/t...ganizacniJednotka	14110

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