About: Sirtuin family: a link to metabolic signaling and senescence

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About: Sirtuin family: a link to metabolic signaling and senescence Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A vast collection of data obtained during the last decade supports the view on sirtuins as sensors of actual cellular metabolic state being involved in cell cycle progression, apoptosis/survival decision making, longevity, inflammation etc. Moreover, sirtuins themselves can control metabolism through their ability to consume NAD+. In turn, cellular NAD parameters may affect the generation of ATP, a main cellular currency of energy. Therefore, sirtuins became recognized as critical affectors of cellular metabolism which participate in fat mobilization, gluconeogenesis, caloric restriction etc. Cellular senescence is viewed as a mechanism to restrict excessive cell growth when it is unnecessary or harmful. It is therefore necessary to understand the mechanism of senescence to design new approaches to combat cancer. Growth in turn depends on metabolism as it requires energy. A vast collection of data obtained during the last decade supports the view on sirtuins as sensors of actual cellular metabolic state being involved in cell cycle progression, apoptosis/survival decision making, longevity, inflammation etc. Moreover, sirtuins themselves can control metabolism through their ability to consume NAD+. In turn, cellular NAD parameters may affect the generation of ATP, a main cellular currency of energy. Therefore, sirtuins became recognized as critical affectors of cellular metabolism which participate in fat mobilization, gluconeogenesis, caloric restriction etc. Cellular senescence is viewed as a mechanism to restrict excessive cell growth when it is unnecessary or harmful. It is therefore necessary to understand the mechanism of senescence to design new approaches to combat cancer. Growth in turn depends on metabolism as it requires energy. (en)
Title	Sirtuin family: a link to metabolic signaling and senescence Sirtuin family: a link to metabolic signaling and senescence (en)
skos:prefLabel	Sirtuin family: a link to metabolic signaling and senescence Sirtuin family: a link to metabolic signaling and senescence (en)
skos:notation	RIV/00216224:14110/10:00046795!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	26
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kyrylenko, Sergiy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	287603
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00046795
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cellular senescence; lifespan; NAD; OAADPr; metabolism; histone deacetylase; resveratrol; p53 (en)
http://linked.open.../riv/klicoveSlovo	lifespan metabolism p53 histone deacetylase NAD resveratrol Cellular senescence OAADPr
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[3BA248B97852]
http://linked.open...i/riv/nazevZdroje	Current Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Kyrylenko, Sergiy Baniahmad, A.
http://linked.open...ain/vavai/riv/wos	000280524400007
issn	0929-8673
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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