About: Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model

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About: Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There is a growing body of evidence that cytokines contribute to both induction and maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG). We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling. Unilateral CCI of the rat sciatic nerve induced mechanoallodynia and thermal hyperalgesia in ipsilateral hind paws, but contralateral paws exhibited only temporal changes of sensitivity. We demonstrated that IL-6 mRNA and protein, which were expressed at very low levels in naive DRG, were bilaterally increased not only in L4-L5 DRG neurons but also in SGC activated by unilateral CCI. There is a growing body of evidence that cytokines contribute to both induction and maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG). We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling. Unilateral CCI of the rat sciatic nerve induced mechanoallodynia and thermal hyperalgesia in ipsilateral hind paws, but contralateral paws exhibited only temporal changes of sensitivity. We demonstrated that IL-6 mRNA and protein, which were expressed at very low levels in naive DRG, were bilaterally increased not only in L4-L5 DRG neurons but also in SGC activated by unilateral CCI. (en)
Title	Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model (en)
skos:prefLabel	Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model (en)
skos:notation	RIV/00216224:14110/10:00045288!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/07/0121), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hradilová Svíženská, Ivana Brázda, Václav Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	286377
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00045288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neuroinflammation; cytokine; unilateral nerve injury; contralateral (en)
http://linked.open.../riv/klicoveSlovo	unilateral nerve injury neuroinflammation contralateral cytokine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[533C5480534C]
http://linked.open...i/riv/nazevZdroje	Neuron Glia Biology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	6/2010
http://linked.open...iv/tvurceVysledku	Brázda, Václav Dubový, Petr Hradilová Svíženská, Ivana Klusáková, Ilona
http://linked.open...ain/vavai/riv/wos	000280008500030
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1740-925X
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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