About: Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this work was to study the distribution of heavy metals and of subsequently developed morphological changes in the liver of female mice and their foetuses after oral administration of high doses of lead, mercury, and cadmium (0.03 mg of metal per mouse and day). Heavy metals were administered to pregnant female mice on days 9 to 20 of pregnancy. The animals were euthanised by cervical dislocation. Samples of mother and foetal liver were subsequently collected and processed by means of the common technique for light and electron microscopy. Histochemical reaction based on metal conversion into appropriate sulphide that conjugates with silver was used for detection of heavy metals. Deposits of heavy metals were found at the periphery of lobules of the central vein in the liver of female mice. On the contrary, in the liver of foetuses no predilection site for localisation of the reaction product could be identified. The aim of this work was to study the distribution of heavy metals and of subsequently developed morphological changes in the liver of female mice and their foetuses after oral administration of high doses of lead, mercury, and cadmium (0.03 mg of metal per mouse and day). Heavy metals were administered to pregnant female mice on days 9 to 20 of pregnancy. The animals were euthanised by cervical dislocation. Samples of mother and foetal liver were subsequently collected and processed by means of the common technique for light and electron microscopy. Histochemical reaction based on metal conversion into appropriate sulphide that conjugates with silver was used for detection of heavy metals. Deposits of heavy metals were found at the periphery of lobules of the central vein in the liver of female mice. On the contrary, in the liver of foetuses no predilection site for localisation of the reaction product could be identified. (en)
Title	Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study (en)
skos:prefLabel	Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study (en)
skos:notation	RIV/00216224:14110/10:00044686!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita	S V Z
http://linked.open...avai/riv/aktivity	S, V, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	79
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Krejčířová, Lenka Lauschová, Irena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	254736
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00044686
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cadmium; mercury; lead; histochemical detection; light and electron microscopy; liver; mouse (en)
http://linked.open.../riv/klicoveSlovo	lead light and electron microscopy liver Cadmium mercury mouse histochemical detection
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[89A408BAD89A]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Čížek, Petr Lauschová, Irena Krejčířová, Lenka
http://linked.open...ain/vavai/riv/wos	000280221700008
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0001-7213
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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